Genomic description of acquired fluconazole- and echinocandin-resistance in patients with serial Candida glabrata isolates.

ABSTRACT: Candida glabrata is one of the most common causes of systemic candidiasis, often resistant to antifungal medications. To describe the genomic context of emerging resistance, we conducted a retrospective analysis of 82 serially collected isolates from 33 patients from population-based candidemia surveillance in the United States. We used whole-genome sequencing to determine the genetic relationships between isolates obtained from the same patient. Phylogenetic analysis demonstrated that isolates from 29 patients were clustered by patient. The median SNPs between isolates from the same patient was 30 (range: 7-96 SNPs), while unrelated strains infected four patients. Twenty-one isolates were resistant to echinocandins, and 24 were resistant to fluconazole. All echinocandin-resistant i

SUBMITTER: Misas E 

PROVIDER: S-EPMC10865870 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature