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Genetics of neurosarcoidosis.


ABSTRACT: Sarcoidosis is a systemic, inflammatory, granulomatous disease characterized by great variability in organ involvement, clinical course, and severity. While pulmonary manifestations are almost universal, the central and peripheral nervous systems can also be affected. Neurosarcoidosis occurs in ∼5-15% of cases and is among the manifestations with the highest morbidity and mortality. It is known that sarcoidosis has genetic underpinnings and while multiple studies aimed at identifying associations to sarcoidosis susceptibility and prognosis, very few studies have focused on neurosarcoidosis. This review summarizes the genetic studies to date, compares and contrasts those findings with other genetic effects in sarcoidosis, and offers ideas for moving the field forward.

SUBMITTER: Hardin A 

PROVIDER: S-EPMC10865996 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Genetics of neurosarcoidosis.

Hardin Abigail A   Dawkins Bryan B   Pezant Nathan N   Rasmussen Astrid A   Montgomery Courtney C  

Journal of neuroimmunology 20220829


Sarcoidosis is a systemic, inflammatory, granulomatous disease characterized by great variability in organ involvement, clinical course, and severity. While pulmonary manifestations are almost universal, the central and peripheral nervous systems can also be affected. Neurosarcoidosis occurs in ∼5-15% of cases and is among the manifestations with the highest morbidity and mortality. It is known that sarcoidosis has genetic underpinnings and while multiple studies aimed at identifying association  ...[more]

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