Whole genome sequencing and genotyping <i>Klebsiella pneumoniae</i> multi-drug resistant hospital isolates from Western Kenya.

ABSTRACT:

Objectives

Klebsiella pneumoniae are a frequent cause of nosocomial infections worldwide. Sequence type 147 (ST147) has been reported as a major circulating high-risk lineage in many countries, and appears to be a formidable platform for the dissemination of antimicrobial resistance (AMR) determinants. However, the distribution of this pathogen in Western African hospitals has been scarcely studied. The main objective of this work was to perform whole genome sequencing of K. pneumoniae isolates from a referral hospital in Kakamega (Kenya) for genotyping and identification of AMR and virulence determinants.

Methods

In total, 15 K. pneumoniae isolates showing a broad spectrum antimicrobial resistance were selected for whole genome sequencing by Illu

SUBMITTER: Dinda V 

PROVIDER: S-EPMC10866029 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature