Rise in serum folate after androgen deprivation associated with worse prostate cancer-specific survival.

ABSTRACT:

Introduction

High folate has an association with advanced prostate cancer and levels of testosterone. Herein, we perform a translational study to investigate the inverse response of serum folate in prostate cancer patients initiating androgen deprivation therapy (ADT) and a mirrored animal model.

Methods

A retrospective study was performed using the South Texas Veterans Healthcare System to identify patients with prostate cancer on ADT. We documented testosterone and folate levels before and after ADT initiation (defined by a reduction in testosterone by 50 ng/ml) as compared to those already on ADT (maintenance). Our primary outcome was overall mortality with secondary outcome of prostate cancer-specific mortality. In parallel, we tested castration of C57BL/6J mice on folat

SUBMITTER: Liss MA 

PROVIDER: S-EPMC10866043 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature