Genomic analysis of lineage-specific transmission of multidrug resistance tuberculosis in China.

ABSTRACT:

Objectives

We investigated the genetic diversities and lineage-specific transmission dynamics of multidrug-resistant tuberculosis (MDR-TB), with the goal of determining the potential factors driving the MDR epidemics in China.

Methods

We curated a large nationwide Mycobacterium tuberculosis (M. tuberculosis) whole genome sequence data set, including 1313 MDR strains. We reconstructed the phylogeny and mapped the transmission networks of MDR-TB across China using Bayesian inference. To identify drug-resistance variants linked to enhanced transmissibility, we employed ordinary least-squares (OLS) regression analysis.

Result

The majority of MDR-TB strains in China belong to lineage 2.2.1. Transmission chain analysis has indicated that the repeated and frequ

SUBMITTER: Li YF 

PROVIDER: S-EPMC10866052 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature