Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties.

ABSTRACT: Cancer is one of the most significant health challenges worldwide. Various techniques, tools and therapeutics/materials have been developed in the last few decades for the treatment of cancer, together with great interest, funding and efforts from the scientific society. However, all the reported studies and efforts seem insufficient to combat the various types of cancer, especially the advanced ones. The overexpression of tyrosine kinases is associated with cancer proliferation and/or metastasis. VEGF, an important category of tyrosine kinases, and its receptors (VEGFR) are hyper-activated in different cancers. Accordingly, they are known as important factors in the angiogenesis of different tumors and are considered in the development of effective therapeutic approaches for controlling m

SUBMITTER: Aboshouk DR 

PROVIDER: S-EPMC10866129 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature