Comparative neural correlates of DBS and MRgFUS lesioning for tremor control in essential tremor.

ABSTRACT:

Background

Given high rates of early complications and non-reversibility, refined targeting is necessitated for magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy for essential tremor (ET). Selection of lesion location can be informed by considering optimal stimulation area from deep brain stimulation (DBS).

Methods

118 patients with ET who received DBS (39) or MRgFUS (79) of the ventral intermediate nucleus (VIM) underwent stimulation/lesion mapping, probabilistic mapping of clinical efficacy and normative structural connectivity analysis. The efficacy maps were compared, which depict the relationship between stimulation/lesion location and clinical outcome.

Results

Efficacy maps overlap around the VIM ventral border and encompass the dentato-rubro-tha

SUBMITTER: Germann J 

PROVIDER: S-EPMC10866130 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature