Prognostic significance of senescence-related tumor microenvironment genes in head and neck squamous cell carcinoma.

ABSTRACT: The impact of the senescence related microenvironment on cancer prognosis and therapeutic response remains poorly understood. In this study, we investigated the prognostic significance of senescence related tumor microenvironment genes (PSTGs) and their potential implications for immunotherapy response. Using the Cancer Genome Atlas- head and neck squamous cell carcinoma (HNSC) data, we identified two subtypes based on the expression of PSTGs, acquired from tumor-associated senescence genes, tumor microenvironment (TME)-related genes, and immune-related genes, using consensus clustering. Using the LASSO, we constructed a risk model consisting of senescence related TME core genes (STCGs). The two subtypes exhibited significant differences in prognosis, genetic alterations, methylation patte

SUBMITTER: Lee YC 

PROVIDER: S-EPMC10866405 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature