Potential prognosis and immunotherapy predictor TFAP2A in pan-cancer.

ABSTRACT:

Background

TFAP2A is critical in regulating the expression of various genes, affecting various biological processes and driving tumorigenesis and tumor development. However, the significance of TFAP2A in carcinogenesis processes remains obscure.

Methods

In our study, we explored multiple databases including TCGA, GTEx, HPA, cBioPortal, TCIA, and other well-established databases for further analysis to expound TFAP2A expression, genetic alternations, and their relationship with the prognosis and cellular signaling network alternations. GO term and KEGG pathway enrichment analysis as well as GSEA were conducted to examine the common functions of TFAP2A. RT-qPCR, Western Blot and Dual Luciferase Reporter assay were employed to perform experimental validation.

Results

TFA

SUBMITTER: Niu C 

PROVIDER: S-EPMC10866441 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature