Gut microbial community and fecal metabolomic signatures in different types of osteoporosis animal models.

ABSTRACT:

Background

The gut microbiota (GM) constitutes a critical factor in the maintenance of physiological homeostasis. Numerous studies have empirically demonstrated that the GM is closely associated with the onset and progression of osteoporosis (OP). Nevertheless, the characteristics of the GM and its metabolites related to different forms of OP are poorly understood. In the present study, we examined the changes in the GM and its metabolites associated with various types of OP as well as the correlations among them.

Methods

We simultaneously established rat postmenopausal, disuse-induced, and glucocorticoid-induced OP models. We used micro-CT and histological analyses to observe bone microstructure, three-point bending tests to measure bone strength, and enzyme-linked immunoso

SUBMITTER: Qiao X 

PROVIDER: S-EPMC10866450 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature