Real-world effectiveness of pharmacological treatments for bipolar disorder: register-based national cohort study.

ABSTRACT:

Background

Pharmacological treatment patterns for bipolar disorder have changed during recent years, but for better or worse?

Aims

To investigate the comparative real-world effectiveness of antipsychotics and mood stabilisers in bipolar disorder.

Method

Register-based cohort study including all Finnish residents aged 16-65 with a diagnosis of bipolar disorder from in-patient care, specialised out-patient care, sickness absence and disability pensions registers between 1996 and 2018, with a mean follow-up of 9.3 years (s.d. = 6.4). Antipsychotic and mood stabiliser use was modelled using the PRE2DUP method and risk for hospital admission for psychiatric and non-psychiatric reasons when using versus not using medications was estimated using within-individual Cox models.

SUBMITTER: Lahteenvuo M 

PROVIDER: S-EPMC10866673 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature