Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture.

ABSTRACT: Morphogenesis and cell state transitions must be coordinated in time and space to produce a functional tissue. An excellent paradigm to understand the coupling of these processes is mammalian hair follicle development, which is initiated by the formation of an epithelial invagination-termed placode-that coincides with the emergence of a designated hair follicle stem cell population. The mechanisms directing the deformation of the epithelium, cell state transitions and physical compartmentalization of the placode are unknown. Here we identify a key role for coordinated mechanical forces stemming from contractile, proliferative and proteolytic activities across the epithelial and mesenchymal compartments in generating the placode structure. A ring of fibroblast cells gradually wraps around t

SUBMITTER: Villeneuve C 

PROVIDER: S-EPMC10866703 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature