Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization.

ABSTRACT: Contraction and flow of the actin cell cortex have emerged as a common principle by which cells reorganize their cytoplasm and take shape. However, how these cortical flows interact with adjacent cytoplasmic components, changing their form and localization, and how this affects cytoplasmic organization and cell shape remains unclear. Here we show that in ascidian oocytes, the cooperative activities of cortical actomyosin flows and deformation of the adjacent mitochondria-rich myoplasm drive oocyte cytoplasmic reorganization and shape changes following fertilization. We show that vegetal-directed cortical actomyosin flows, established upon oocyte fertilization, lead to both the accumulation of cortical actin at the vegetal pole of the zygote and compression and local buckling of the adjacen

SUBMITTER: Caballero-Mancebo S 

PROVIDER: S-EPMC10866705 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature