Neuroticism and the Risk of Atrial Fibrillation: An Observational Epidemiologic and Mendelian Randomization Study.

ABSTRACT:

Background

The association between neuroticism and atrial fibrillation (AF) remains unknown.

Objectives

This study aimed to assess the epidemiological and causal relationships between neuroticism and AF.

Methods

Individuals without AF history were selected From the UK Biobank nationwide prospective cohort study. Participants were divided into 2 groups (high and low) based on the median summary score from a self-questionnaire of 12 neurotic behavior domains. The 10-year AF risk was compared between the neuroticism score groups using inverse probability of treatment weighting. The causal relationship between neuroticism and AF was evaluated using a 2-sample summary-level Mendelian randomization with the inverse variance-weighted method.

Results

Of 394,834 partici

SUBMITTER: Rhee TM 

PROVIDER: S-EPMC10866734 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature