An inflamed tumor cell subpopulation promotes chemotherapy resistance in triple negative breast cancer.

ABSTRACT: Individual cancers are composed of heterogeneous tumor cells with distinct phenotypes and genotypes, with triple negative breast cancers (TNBC) demonstrating the most heterogeneity among breast cancer types. Variability in transcriptional phenotypes could meaningfully limit the efficacy of monotherapies and fuel drug resistance, although to an unknown extent. To determine if transcriptional differences between tumor cells lead to differential drug responses we performed single cell RNA-seq on cell line and PDX models of breast cancer revealing cell subpopulations in states associated with resistance to standard-of-care therapies. We found that TNBC models contained a subpopulation in an inflamed cellular state, often also present in human breast cancer samples. Inflamed cells display evide

SUBMITTER: Jacobo Jacobo M 

PROVIDER: S-EPMC10866903 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature