Late-onset vascular complications of radiotherapy for primary brain tumors: a case-control and cross-sectional analysis.

ABSTRACT:

Purpose

Radiotherapy (RT) is a recognized risk factor for cerebrovascular (CV) disease in children and in adults with head and neck cancer. We aimed to investigate whether cerebral RT increases the risk of CV disease in adults with primary brain tumors (PBT).

Methods

We retrospectively identified adults with a supratentorial PBT diagnosed between 1975 and 2006 and with at least 10 years follow-up after treatment. We analyzed demographic, clinical, and radiological features with special attention to CV events. We also described CV events, vascular risk factors, and intracranial artery modifications in a cross-sectional study of irradiated patients alive at the time of the study.

Results

A total of 116 patients, treated with RT (exposed group), and 85 non-irradiated pat

SUBMITTER: Ibanez-Julia MJ 

PROVIDER: S-EPMC10867030 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature