Identification of systemic biomarkers and potential drug targets for age-related macular degeneration.

ABSTRACT:

Purpose

Since age-related macular degeneration (AMD) is tightly associated with aging and cellular senescence, objective of this study was to investigate the association between plasma levels of senescence-related proteins (SRPs) and risk of AMD.

Design

The whole study was based on two-sample Mendelian randomization (MR) analysis.

Methods

For MR analysis, the primary approach for MR analysis was the inverse-variance weighted (IVW) method and the heterogeneity and pleiotropy of results were tested. The instrumental single-nucleotide polymorphisms (SNPs) associated with 110 SRPs were filtered and selected from a large genome-wide association study (GWAS) for plasma proteome involving 35,559 participants. The GWAS data of AMD was obtained from FinnGen consortium (6,157 A

SUBMITTER: Lei S 

PROVIDER: S-EPMC10867226 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature