Associations of educational attainment with Sepsis mediated by metabolism traits and smoking: a Mendelian randomization study.

ABSTRACT:

Objective

Sepsis constitutes a significant global healthcare burden. Studies suggest a correlation between educational attainment and the likelihood of developing sepsis. Our goal was to utilize Mendelian randomization (MR) in order to examine the causal connection between educational achievement (EA) and sepsis, while measuring the mediating impacts of adjustable variables.

Methods

We collected statistical data summarizing educational achievement (EA), mediators, and sepsis from genome-wide association studies (GWAS). Employing a two-sample Mendelian randomization (MR) approach, we calculated the causal impact of education on sepsis. Following this, we performed multivariable MR analyses to assess the mediation proportions of various mediators, including body mass index (BM

SUBMITTER: Lan Y 

PROVIDER: S-EPMC10867269 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature