Decellularized biological matrices for the repair of rotator cuff lesions: a systematic review of preclinical in vivo studies.

ABSTRACT: Background: Rotator cuff tears (RCTs), resulting from degeneration or trauma of the shoulder tendons, are one of the main causes of shoulder pain. In particular, massive RCTs represent 40% of all injuries, require surgical treatment, and are characterized by poor clinical outcomes and a high rate of failure. In recent years, the use of biological decellularized patches for augmentation procedures has received great interest owing to their excellent self-integration properties, improving healing and, thus, presenting an innovative therapeutic option. However, the findings from clinical studies have emerged with conflicting viewpoints regarding the benefits of this procedure, as an excessive tension load might compromise the integrity of the tendon-to-bone connection when the patch ex

SUBMITTER: Codispoti G 

PROVIDER: S-EPMC10867272 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature