Assessing the hazard of death, cardiac tamponade, and pericardial constriction among HIV and tuberculosis pericarditis patients using the extended Cox-hazard model: Intervention study.

ABSTRACT:

Background and aims

Tuberculous (TB) pericarditis (TBP), a TB of the heart, is linked to significant morbidity and mortality rates. Administering glucocorticoid therapy to individuals with TBP might enhance overall results and lower the likelihood of fatality. However, the actual clinical effectiveness of supplementary glucocorticoids remains uncertain. This study specifically evaluated the effects of prednisolone, prednisolone-antiretroviral therapy (ART) interaction, and other potential risk factors in reducing the hazard of the composite outcome, death, cardiac tamponade, and constriction, among TBP and human immunodeficiency virus (HIV) patients.

Methods

The data used in this study were obtained from the investigation of the Management of Pericarditis trial, a multicentr

SUBMITTER: Iddrisu AK 

PROVIDER: S-EPMC10867395 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature