Maternal metabolic profiling across body mass index groups: An exploratory longitudinal study.

ABSTRACT:

Introduction

Increased BMI has been identified as a risk factor for most pregnancy complications, but the underlying metabolic factors mediating the detrimental effects of BMI are largely unknown. We aimed to compare metabolic profiles in overweight/obese women (body mass index [BMI] ≥ 25 kg/m² ) and normal weight/underweight women (BMI < 25 kg/m² ) across gestation. We also explored how gestational weight gain (GWG) affected maternal metabolic profiles.

Material and methods

Exploratory nested case-control study based on a prospective longitudinal cohort of women who were healthy prior to pregnancy and gave birth at Oslo University Hospital from 2002 to 2008. The sample consisted of 48 women who were overweight/obese and 59 normal-weight/underweight wom

SUBMITTER: Skytte HN 

PROVIDER: S-EPMC10867396 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature