Prognostic value of circulating short-length DNA fragments in unresected glioblastoma patients.

ABSTRACT:

Background

Liquid biopsy application is still challenging in glioblastoma patients and the usefulness of short-length DNA (slDNA) fragments is not established. The aim was to investigate slDNA concentration as a prognostic marker in unresected glioblastoma patients.

Methods

Patients with unresected glioblastoma and treated by radiochemotherapy (RT/TMZ) were included. Plasmas were prospectively collected at three times: before (pre-) RT, after (post-) RT and at the time of progression. Primary objective was to investigate the impact on survival of slDNA concentration [slDNA] variation during RT/TMZ. Secondary objectives were to explore the association between tumor volume, corticosteroid exposition and [slDNA]; and the impact of slDNA detection at pre-RT on survival.

Resul

SUBMITTER: Daban A 

PROVIDER: S-EPMC10867437 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature