Rapidly progressive interstitial lung disease risk prediction in anti-MDA5 positive dermatomyositis: the CROSS model.

ABSTRACT:

Background

The prognosis of anti-melanoma differentiation-associated gene 5 positive dermatomyositis (anti-MDA5⁺DM) is poor and heterogeneous. Rapidly progressive interstitial lung disease (RP-ILD) is these patients' leading cause of death. We sought to develop prediction models for RP-ILD risk in anti-MDA5⁺DM patients.

Methods

Patients with anti-MDA5⁺DM were enrolled in two cohorts: 170 patients from the southern region of Jiangsu province (discovery cohort) and 85 patients from the northern region of Jiangsu province (validation cohort). Cox proportional hazards models were used to identify risk factors of RP-ILD. RP-ILD risk prediction models were developed and validated by testing every independent prognostic risk factor derived from the

SUBMITTER: Wang L 

PROVIDER: S-EPMC10867574 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature