Dietary docosahexaenoic acid supplementation inhibits acute pulmonary transcriptional and autoantibody responses to a single crystalline silica exposure in lupus-prone mice.

ABSTRACT:

Introduction

Workplace exposure to respirable crystalline silica (cSiO₂) has been epidemiologically linked to lupus. Consistent with this, repeated subchronic intranasal cSiO₂ instillation in lupus-prone NZBWF1 mice induces inflammation-/autoimmune-related gene expression, ectopic lymphoid tissue (ELT), autoantibody (AAb) production in the lung within 5 to 13 wk followed systemic AAb increases and accelerated onset and progression of glomerulonephritis within 13 to 17 wk. Interestingly, dietary docosahexaenoic acid (DHA) supplementation suppresses these pathologic effects, but the underlying molecular mechanisms remain unclear.

Methods

This study aimed to test the hypothesis that dietary DHA supplementation impacts acute transcriptional and autoantibody

SUBMITTER: Chauhan PS 

PROVIDER: S-EPMC10867581 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature