Time-resolved map of serum metabolome profiling in D-galactose-induced aging rats with exercise intervention.

ABSTRACT: Exercise, an intervention with wide-ranging effects on the whole body, has been shown to delay aging. Due to aging and exercise as modulator of metabolism, a picture of how exercise delayed D-galactose (D-gal)-induced aging in a time-resolved manner was presented in this paper. The mapping of molecular changes in response to exercise has become increasingly accessible with the development of omics techniques. To explore the dynamic changes during exercise, the serum of rats and D-gal-induced aging rats before, during, and after exercise was analyzed by untargeted metabolomics. The variation of metabolites was monitored to reveal the specific response to D-gal-induced senescence and exercise in multiple pathways, especially the basal amino acid metabolism, including glycine serine and threo

SUBMITTER: Li X 

PROVIDER: S-EPMC10867647 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature