The impact of psychiatric comorbidity on Parkinson's disease outcomes: a systematic review and meta-analysis.

ABSTRACT:

Background

The burden of psychiatric symptoms in Parkinson's disease includes depression, anxiety, apathy, psychosis, and impulse control disorders. However, the relationship between psychiatric comorbidities and subsequent prognosis and neurological outcomes is not yet well understood. In this systematic review and meta-analysis, in individuals with Parkinson's disease, we aimed to characterise the association between specific psychiatric comorbidities and subsequent prognosis and neurological outcomes: cognitive impairment, death, disability, disease progression, falls or fractures and care home admission.

Methods

We searched MEDLINE, Embase, PsycINFO and AMED up to 13th November 2023 for longitudinal observational studies which measured disease outcomes in people with Par

SUBMITTER: Burchill E 

PROVIDER: S-EPMC10867667 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature