Prescription Opioid Exposure During Pregnancy and Risk of Spontaneous Preterm Delivery.

ABSTRACT:

Importance

Opioid exposure during pregnancy has been associated with preterm birth, but prior studies have not differentiated between spontaneous and indicated preterm birth or fully investigated these associations as functions of opioid dose.

Objective

To determine whether prescription opioid use during pregnancy is associated with spontaneous preterm birth and whether the association is dose-dependent.

Design, setting, and participants

This case-control study examined a retrospective cohort of pregnant patients enrolled in Tennessee Medicaid. Enrollment files were linked to health care encounters, hospital discharge information, birth certificate data, and prescription fills. Eligible participants were pregnant people ages 15 to 44 years without opioid use disorder

SUBMITTER: Bosworth OM 

PROVIDER: S-EPMC10867678 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature