Cost-Effectiveness of Population-Based Multigene Testing for Breast and Ovarian Cancer Prevention.

ABSTRACT:

Importance

The current method of BRCA testing for breast and ovarian cancer prevention, which is based on family history, often fails to identify many carriers of pathogenic variants. Population-based genetic testing offers a transformative approach in cancer prevention by allowing for proactive identification of any high-risk individuals and enabling early interventions.

Objective

To assess the lifetime incremental effectiveness, costs, and cost-effectiveness of population-based multigene testing vs family history-based testing.

Design, setting, and participants

This economic evaluation used a microsimulation model to assess the cost-effectiveness of multigene testing (BRCA1, BRCA2, and PALB2) for all women aged 30 to 35 years compared with the current standard of ca

SUBMITTER: Guo F 

PROVIDER: S-EPMC10867683 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature