Potential drug-induced constipation: A retrospective study using a Japanese claims database.

ABSTRACT:

Background and aim

Detailed clinical information regarding drug-induced constipation (DIC) is limited. This study aimed to investigate the real-world situation of DIC.

Methods

This retrospective study used data from a Japanese claims database registered from 2014 to 2021. The constipation cohort included subjects with at least one record of treated constipation, while the non-constipation cohort was selected through random stratified sampling method, to match the constipation cohort by gender. The study population and control with at least one history of a known causative drug (CD) were matched 1:1 using propensity scores. The proportion of potential DIC (pDIC), the timing of diagnosis for pDIC, and the proportion of prescriptions by drug class for both the CDs and the laxat

SUBMITTER: Karasawa Y 

PROVIDER: S-EPMC10867697 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature