Sex Differences in Diagnosis, Treatment, and Cardiovascular Outcomes in Homozygous Familial Hypercholesterolemia.

ABSTRACT:

Importance

Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition characterized by extremely increased low-density lipoprotein (LDL) cholesterol levels and premature atherosclerotic cardiovascular disease (ASCVD). Heterozygous familial hypercholesterolemia (HeFH) is more common than HoFH, and women with HeFH are diagnosed later and undertreated compared to men; it is unknown whether these sex differences also apply to HoFH.

Objective

To investigate sex differences in age at diagnosis, risk factors, lipid-lowering treatment, and ASCVD morbidity and mortality in patients with HoFH.

Design, setting, and participants

Sex-specific analyses for this retrospective cohort study were performed using data from the HoFH International Clinical Collaborators (

SUBMITTER: Mulder JWCM 

PROVIDER: S-EPMC10867777 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature