Urolithin A attenuates arsenic-induced gut barrier dysfunction.

ABSTRACT: Environmental chemicals such as inorganic arsenic (iAs) significantly contribute to redox toxicity in the human body by enhancing oxidative stress. Imbalanced oxidative stress rapidly interferes with gut homeostasis and affects variety of cellular processes such as proliferation, apoptosis, and maintenance of intestinal barrier integrity. It has been shown that gut microbiota are essential to protect against iAs³⁺-induced toxicity. However, the effect of microbial metabolites on iAs³⁺-induced toxicity and loss of gut barrier integrity has not been investigated. The objectives of the study are to investigate impact of iAs on gut barrier function and determine benefits of gut microbial metabolite, urolithin A (UroA) against iAs³⁺-induced adversaries on gut ep

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC10867785 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature