Inhibiting acid-sensing ion channel exerts neuroprotective effects in experimental epilepsy via suppressing ferroptosis.

ABSTRACT:

Background

Epilepsy is a chronic neurological disease characterized by repeated and unprovoked epileptic seizures. Developing disease-modifying therapies (DMTs) has become important in epilepsy studies. Notably, focusing on iron metabolism and ferroptosis might be a strategy of DMTs for epilepsy. Blocking the acid-sensing ion channel 1a (ASIC1a) has been reported to protect the brain from ischemic injury by reducing the toxicity of [Ca²⁺ ]_i . However, whether inhibiting ASIC1a could exert neuroprotective effects and become a novel target for DMTs, such as rescuing the ferroptosis following epilepsy, remains unknown.

Methods

In our study, we explored the changes in ferroptosis-related indices, including glutathione peroxidase (GPx) enzyme activity and le

SUBMITTER: Shi X 

PROVIDER: S-EPMC10867794 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature