The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study.

ABSTRACT:

Background

Genome-wide association studies have reported a genetic overlap between borderline personality disorder (BPD) and schizophrenia (SCZ). Epidemiologically, the direction and causality of the association between thyroid function and risk of BPD and SCZ are unclear. We aim to test whether genetically predicted variations in TSH and FT4 levels or hypothyroidism are associated with the risk of BPD and SCZ.

Methods

We employed Mendelian Randomisation (MR) analyses using genetic instruments associated with TSH and FT4 levels as well as hypothyroidism to examine the effects of genetically predicted thyroid function on BPD and SCZ risk. Bidirectional MR analyses were employed to investigate a potential reverse causal association.

Results

Genetically predicted higher

SUBMITTER: Babajide O 

PROVIDER: S-EPMC10868101 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature