PERFUMES: pipeline to extract RNA functional motifs and exposed structures.

ABSTRACT:

Motivation

Up to 75% of the human genome encodes RNAs. The function of many non-coding RNAs relies on their ability to fold into 3D structures. Specifically, nucleotides inside secondary structure loops form non-canonical base pairs that help stabilize complex local 3D structures. These RNA 3D motifs can promote specific interactions with other molecules or serve as catalytic sites.

Results

We introduce PERFUMES, a computational pipeline to identify 3D motifs that can be associated with observable features. Given a set of RNA sequences with associated binary experimental measurements, PERFUMES searches for RNA 3D motifs using BayesPairing2 and extracts those that are over-represented in the set of positive sequences. It also conducts a thermodynamics analysis of the structur

SUBMITTER: Chol A 

PROVIDER: S-EPMC10868343 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature