Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies.

ABSTRACT:

Background

Phytonutrient intakes may improve outcomes following breast cancer, but the impact of postdiagnosis introduction vs established prediagnostic exposure as well as optimum doses has not been established. Evidence from observational studies for key exposures was evaluated, including dosage and intake time frames.

Methods

MEDLINE, EMBASE, CINAHL, Cochrane Library, ClinicalTrials.gov, and the ISRCTN registry were searched for prospective and retrospective observational studies investigating the impact of soybean, lignans, cruciferous (cabbage-family) vegetables, green tea, or their phytonutrients on breast cancer survival outcomes. A random-effects model was used to calculate summary hazard ratios (HRs) and 95% confidence intervals (CIs). Nonlinear dose-response analys

SUBMITTER: van Die MD 

PROVIDER: S-EPMC10868383 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature