A PDZ scaffolding/CaM-mediated pathway in Cryptochrome signaling.

ABSTRACT: Cryptochromes are cardinal constituents of the circadian clock, which orchestrates daily physiological rhythms in living organisms. A growing body of evidence points to their participation in pathways that have not traditionally been associated with circadian clock regulation, implying that cryptochromes may be subject to modulation by multiple signaling mechanisms. In this study, we demonstrate that human CRY2 (hCRY2) forms a complex with the large, modular scaffolding protein known as Multi-PDZ Domain Protein 1 (MUPP1). This interaction is facilitated by the calcium-binding protein Calmodulin (CaM) in a calcium-dependent manner. Our findings suggest a novel cooperative mechanism for the regulation of mammalian cryptochromes, mediated by calcium ions (Ca²⁺ ) and CaM. We propose

SUBMITTER: Bellanda M 

PROVIDER: S-EPMC10868427 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature