Key interaction networks: Identifying evolutionarily conserved non-covalent interaction networks across protein families.

ABSTRACT: Protein structure (and thus function) is dictated by non-covalent interaction networks. These can be highly evolutionarily conserved across protein families, the members of which can diverge in sequence and evolutionary history. Here we present KIN, a tool to identify and analyze conserved non-covalent interaction networks across evolutionarily related groups of proteins. KIN is available for download under a GNU General Public License, version 2, from https://www.github.com/kamerlinlab/KIN. KIN can operate on experimentally determined structures, predicted structures, or molecular dynamics trajectories, providing insight into both conserved and missing interactions across evolutionarily related proteins. This provides useful insight both into protein evolution, as well as a tool that can

SUBMITTER: Yehorova D 

PROVIDER: S-EPMC10868456 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature