Investigation of Allogeneic Neutrophil Transfusion in Improving Survival Rates of Severe Infection Mice.

ABSTRACT: The management of granulocytopenia-associated infections is challenging, and a high mortality rate is associated with traditional supportive therapies. Neutrophils-the primary defenders of the human immune system-have potent bactericidal capabilities. Here, we investigated the dynamic in vivo distribution of neutrophil transfusion and their impact on the treatment outcome of severe granulocytopenic infections. We transfused ⁸⁹Zr-labeled neutrophils in the C57BL/6 mice and observed the dynamic neutrophil distribution in mice for 24 h using the micro-positron emission tomography (Micro-PET) technique. The labeled neutrophils were predominantly retained in the lungs and spleen up to 4 h after injection and then redistributed to other organs, such as the spleen, liver, and bone marr

SUBMITTER: Li L 

PROVIDER: S-EPMC10868470 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature