Rational and trial design of FASCINATE-N: a prospective, randomized, precision-based umbrella trial.

ABSTRACT:

Background

With our growing insight into the molecular heterogeneity and biological characteristics of breast cancer, individualized treatment is the future of cancer treatment. In this prospective Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series study - neoadjuvant therapy (FASCINATE-N) trial, we classify breast cancer patients using multiomic characteristics into different subtypes to evaluate the efficacy of precision-based targeted therapies compared to standard neoadjuvant chemotherapy.

Methods and design

The FASCINATE-N trial is a prospective, randomized, precision-based umbrella trial that plans to enroll 716 women with early breast cancer. After enrollment, patients will first be divided into three groups: hormone receptor (HR)+/human e

SUBMITTER: Zuo WJ 

PROVIDER: S-EPMC10868472 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature