Effect of treatment with growth hormone on body composition and metabolic profile of short children born small for gestational age.

ABSTRACT:

Objective

To assess the effect of recombinant growth hormone (rGH) on body composition and metabolic profile of prepubertal short children born small for gestational age (SGA) before and after 18 months of treatment.

Methods

It is a clinical, non-randomized, and paired study. Children born SGA, with birth weight and/or length <-2 standard deviations (SD) for gestational age and sex, prepubertal, born at full term, of both genders, with the indication for treatment with rGH were included. The intervention was performed with biosynthetic rGH at doses ranging from 0.03 to 0.05 mg/kg/day, administered subcutaneously, once a day at bedtime. Total lean mass (LM) and total fat mass (FM) were carried out using dual-energy X-ray absorptiometry (DXA), and the metabolic profile was ass

SUBMITTER: Kuhl AM 

PROVIDER: S-EPMC10868514 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature