Gut microbiota-derived trimethylamine N-Oxide: a novel target for the treatment of preeclampsia.

ABSTRACT: Pre-eclampsia (PE) is the most common complication of pregnancy and seriously threatens the health and safety of the mother and child. Studies have shown that an imbalance in gut microbiota can affect the progression of PE. Trimethylamine N-oxide (TMAO) is an intestinal microbiota-derived metabolite that is thought to be involved in the occurrence of PE; however, its causal relationship and mechanism remain unclear. In this clinical cohort study, including 28 patients with eclampsia and 39 matched healthy controls, fecal samples were collected for 16S rRNA gene sequencing, and serum was collected for targeted metabolomics research. The results showed that the level of TMAO and the abundance of its source bacteria had significantly increased in patients with PE, and were positively correlat

SUBMITTER: Wang J 

PROVIDER: S-EPMC10868535 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature