Recent advances on the structure and the function relationships of the TRPV4 ion channel.

ABSTRACT: The members of the superfamily of Transient Receptor Potential (TRP) ion channels are physiologically important molecules that have been studied for many years and are still being intensively researched. Among the vanilloid TRP subfamily, the TRPV4 ion channel is an interesting protein due to its involvement in several essential physiological processes and in the development of various diseases. As in other proteins, changes in its function that lead to the development of pathological states, have been closely associated with modification of its regulation by different molecules, but also by the appearance of mutations which affect the structure and gating of the channel. In the last few years, some structures for the TRPV4 channel have been solved. Due to the importance of this protein in

SUBMITTER: Sanchez-Hernandez R 

PROVIDER: S-EPMC10868539 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature