Genomic, Proteomic, and Phenotypic Biomarkers of COVID-19 Severity: Protocol for a Retrospective Observational Study.

ABSTRACT:

Background

Health organizations and countries around the world have found it difficult to control the spread of COVID-19. To minimize the future impact on the UK National Health Service and improve patient care, there is a pressing need to identify individuals who are at a higher risk of being hospitalized because of severe COVID-19. Early targeted work was successful in identifying angiotensin-converting enzyme-2 receptors and type II transmembrane serine protease dependency as drivers of severe infection. Although a targeted approach highlights key pathways, a multiomics approach will provide a clearer and more comprehensive picture of severe COVID-19 etiology and progression.

Objective

The COVID-19 Response Study aims to carry out an integrated multiomics analysis to iden

SUBMITTER: English A 

PROVIDER: S-EPMC10868637 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature