Direct comparison between ¹⁸F-Flortaucipir tau PET and quantitative susceptibility mapping in progressive supranuclear palsy.

ABSTRACT:

Purpose

The pattern of flortaucipir tau PET uptake is topographically similar to the pattern of magnetic susceptibility in progressive supranuclear palsy (PSP); both with increased signal in subcortical structures such as the basal ganglia and midbrain, suggesting that they may be closely related. However, their relationship remains unknown since no studies have directly compared these two modalities in the same PSP cohort. We hypothesized that some flortaucipir uptake in PSP is associated with magnetic susceptibility, and hence iron deposition. The aim of this study was to evaluate the regional relationship between flortaucipir uptake and magnetic susceptibility and to examine the effects of susceptibility on flortaucipir uptake in PSP.

Methods

Fifty PSP patients and 67 cog

SUBMITTER: Satoh R 

PROVIDER: S-EPMC10868646 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature