Distinct roles for type I and type III interferons in virulent human metapneumovirus pathogenesis.

ABSTRACT: Human metapneumovirus (HMPV) is an important cause of acute lower respiratory infection in children and adults worldwide. There are four genetic subgroups of HMPV and both neutralizing antibodies and T cells contribute to protection. However, little is known about mechanisms of pathogenesis and most published work is based on a few extensively passaged, laboratory-adapted strains of HMPV. In this study, we isolated and characterized a panel of low passage HMPV clinical isolates representing all four genetic subgroups. The clinical isolates exhibited lower levels of in vitro replication compared to a lab-adapted strain. We compared disease phenotypes using a well-established mouse model. Several virulent isolates caused severe weight loss, lung pathology, airway dysfunction, and fatal disea

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10868789 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature