Potential mechanisms and drug prediction of Rheumatoid Arthritis and primary Sjogren's Syndrome: A public databases-based study.

ABSTRACT: Rheumatoid arthritis (RA) and primary Sjögren's syndrome (pSS) are the most common systemic autoimmune diseases, and they are increasingly being recognized as occurring in the same patient population. These two diseases share several clinical features and laboratory parameters, but the exact mechanism of their co-pathogenesis remains unclear. The intention of this study was to investigate the common molecular mechanisms involved in RA and pSS using integrated bioinformatic analysis. RNA-seq data for RA and pSS were picked up from the Gene Expression Omnibus (GEO) database. Co-expression genes linked with RA and pSS were recognized using weighted gene co-expression network analysis (WGCNA) and differentially expressed gene (DEG) analysis. Then, we screened two public disease-gene interactio

SUBMITTER: Wu L 

PROVIDER: S-EPMC10868835 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature