Index analysis: An approach to understand signal transduction with application to the EGFR signalling pathway.

ABSTRACT: In systems biology and pharmacology, large-scale kinetic models are used to study the dynamic response of a system to a specific input or stimulus. While in many applications, a deeper understanding of the input-response behaviour is highly desirable, it is often hindered by the large number of molecular species and the complexity of the interactions. An approach that identifies key molecular species for a given input-response relationship and characterises dynamic properties of states is therefore highly desirable. We introduce the concept of index analysis; it is based on different time- and state-dependent quantities (indices) to identify important dynamic characteristics of molecular species. All indices are defined for a specific pair of input and response variables as well as for a s

SUBMITTER: Knochel J 

PROVIDER: S-EPMC10868873 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature