Williams-Beuren syndrome in pediatric T-cell acute lymphoblastic leukemia: A rare case report and review of literature.

ABSTRACT:

Background

Williams-Beuren syndrome (WBS) is a rare genetic disorder caused by hemizygous microdeletion of contiguous genes on chromosome 7q11.23. Although the phenotype features extensive heterogeneity in severity and performance, WBS is not considered to be a predisposing factor for cancer development. Currently, hematologic cancers, mainly Burkitt lymphoma, are rarely reported in patients with WBS. Here in, we report a unique case of T-cell acute lymphoblastic leukemia in a male child with WBS.

Methods

This retrospective study analyzed the clinical data of this case receiving chemotherapy were analyzed. This is a retrospective study.

Results

The patient, who exhibited a typical WBS phenotype and presented with hemorrhagic spots. Chromosomal genome-wide chip analysi

SUBMITTER: Yang R 

PROVIDER: S-EPMC10869033 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature