Temporal relationship between inflammation and metabolic disorders and their impact on cancer risk.

ABSTRACT:

Background

Inflammation and metabolic disorders are closely associated with cancer. Whether inflammation leads to metabolic disorders or vice versa during cancer initiation remains unclear. In this study, we explored this temporal relationship and the co-exposure effect on cancer risk.

Methods

This prospective study had two phases. Initially, we examined the temporal relationship between inflammation (high-sensitivity C-reactive protein (CRP)) and metabolic disorders (metabolic syndrome severity Z-score (MetS-Z)) using a 3.98-year survey and cross-lagged analysis. Subsequently, we assessed the connection of co-exposure to inflammation and metabolic disorders, and the risks of overall cancer, as well as specific obesity-related, non-obesity-related, digestive system, lung, an

SUBMITTER: Liu C 

PROVIDER: S-EPMC10869135 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature