Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue.

ABSTRACT: Mitochondria are required for energy production and even give brown adipose tissue (BAT) its characteristic color due to their high iron content and abundance. The physiological function and bioenergetic capacity of mitochondria are connected to the structure, folding, and organization of its inner-membrane cristae. During the aging process, mitochondrial dysfunction is observed, and the regulatory balance of mitochondrial dynamics is often disrupted, leading to increased mitochondrial fragmentation in aging cells. Therefore, it is hypothesized that significant morphological changes in BAT mitochondria and cristae will be present with aging. A quantitative 3D electron microscopy approach is developed to map cristae network organization in mouse BAT to test this hypothesis. Using this metho

SUBMITTER: Crabtree A 

PROVIDER: S-EPMC10869235 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature